Department of Physics and Biophysics/Institute of Biology
Warsaw University of Life Sciences, Warsaw, Poland
We are seeking a highly motivated and talented PhD student to join our research team at the Department of Physics and Biophysics, Institute of Biology at Warsaw University of Life Sciences. This position is a valuable opportunity for a passionate individual to contribute to cutting-edge research in the field of T cell biology and immune response, with a specific focus on the role of Transient Receptor Potential Ankyrin 1 (TRPA1) and Melastatin 2 (TRPM2) channels in relation to hypoxia and the regulation of immune response.
Project Overview:
The primary objective of this project is to investigate the role of TRPA1 and TRPM2 channels in the physiology of T cells, particularly in relation to hypoxia and their potential involvement in the regulation of immune response. T lymphocytes, as crucial components of the adaptive immune system, play a pivotal role in combating pathogens, including viruses, and are involved in cancer and autoimmune disorders. However, the intricate regulation of T cell functioning is influenced by multiple factors, such as temperature, pH, and hypoxia. Hypoxia, in particular, is known to have a detrimental impact on T cell physiology, affecting their activation, cytotoxicity, and metabolism. The project aims to explore the link between hypoxia-sensing, TRPA1 and TRPM2 channels, and their potential influence on T cells physiology. Czytaj dalej
